منابع مشابه
William Harvey (1578-1657)
Renowned physician and scientist William Harvey [4] is best known for his accurate description of how blood circulates through the body. While his published work on the circulation of blood is considered the most important of his academic life, Harvey also made significant contributions to embryology [5] with the publication of his book Exercitationes de Generatione Animalium [6] in 1651. In th...
متن کاملDmm021428 1569..1578
Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by conduction defects and supraventricular and ventricular tachycardia, and carries a high risk of sudden cardiac death. Despite its importance, very f...
متن کاملRan
How is Ran involved in nuclear transport? Cargo is transported through pores in the nuclear envelope, in association with carriers that bind to pore proteins called nucleoporins. A Ran–GTP gradient across the envelope is created by the asymmetric distribution of the GTPase activating protein known as RanGAP, which is in the cytosol, and of the guanine nucleotide exchange factor RanGEF in the nu...
متن کاملSmall GTPase Ran and Ran-binding proteins.
Abstract Like many other small GTPases, Ran functions in eukaryotic cells as a molecular switch that cycles between GTP- and GDP-bound forms. Through the proper modulation of the GTP/GDP cycle, Ran functions with a number of Ran-binding proteins to control a broad array of fundamental cellular functions, including nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope and n...
متن کاملThe ran decathlon: multiple roles of Ran.
The Ran GTPase system affects many cellular processes, including the regulation of cell cycle progression, nuclear envelope structure and function, and nucleocytoplasmic transport. The biochemical basis for the involvement of Ran in nuclear import and export has been well documented, but the direct targets of Ran in other cellular processes have not yet been identified. There is, however, mount...
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ژورنال
عنوان ژورنال: Philologus
سال: 1857
ISSN: 2196-7008,0031-7985
DOI: 10.1524/phil.1857.12.14.530